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However, disease severity, treatment setting, prior antibiotics, and acceptability of the noninferiority margin require consideration when interpreting the findings.

It is unclear how important it is to families that children experience cough for a couple more days with a three day course of amoxicillin.Neither chest radiographs nor inflammatory biomarkers differentiate which children with CAP require antibiotics. Kohns Vasconcelos M, Meyer Sauteur PM, Santoro R, Coslovsky M, Lurà M, Keitel K, Wachinger T, Beglinger S, Heininger U, van den Anker J, Bielicki JA. Children were excluded if they had recent antibiotic treatment (beta-lactam antibiotics for more than 48 hours or any non-beta lactam treatment), severe underlying chronic disease, contraindications to amoxicillin, complicated pneumonia or bacterial wheeze without focal signs. Bielicki JA, Stöhr W, Barratt S, Dunn D, Naufal N, Roland D, Sturgeon K, Finn A, Rodriguez-Ruiz JP, Malhotra-Kumar S, Powell C, Faust SN, Alcock AE, Hall D, Robinson G, Hawcutt DB, Lyttle MD, Gibb DM, Sharland M; PERUKI, GAPRUKI, and the CAP-IT Trial Group. Secondary outcomes included severity/duration of 9 parent-reported CAP symptoms, 3 antibiotic-related adverse events, and phenotypic resistance in colonizing Streptococcus pneumoniae isolates.

Enrollment took place at discharge if inclusion and exclusion criteria were met (eMethods 2 in Supplement 2). The trial was designed to demonstrate noninferiority of lower dose compared with higher dose, and shorter duration compared with longer duration, in terms of the primary end point. We also have a large line of Suspension products and all types of vehicle Racking from the best manufacturers. Bielicki, PhD 1 ; Wolfgang Stöhr, PhD 2 ; Sam Barratt, MPH 2; et al David Dunn, PhD 2 ; Nishdha Naufal, BSc 2 ; Damian Roland, PhD 3,4 ; Kate Sturgeon, MSc 2 ; Adam Finn, PhD 5 ; Juan Pablo Rodriguez-Ruiz, MSc 6 ; Surbhi Malhotra-Kumar, PhD 6 ; Colin Powell, MD 7,8 ; Saul N.

It provides randomised controlled trial evidence in the hospital setting, and the results suggests we should consider changing how we manage children with a clinical diagnosis of CAP. Independent data monitoring committee: Tim Peto (chair), MD, University of Oxford, Oxford, UK; Simon Cousens, DipMathStat, London School of Hygiene and Tropical Medicine, London, UK; and Stuart Logan, MSc, University of Exeter Medical School, Exeter, UK. Independent end point review committee members: Alasdair Bamford (chair), PhD, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; Anna Turkova, MD, MRC CTU, at University College London, London, UK; Anna Goodman, DPhil, Guy’s and St Thomas’ NHS Foundation Trust, London, UK; and Felicity Fitzgerald, PhD, University College London Great Ormond Street Institute of Child Health, London, UK. of subjects had face to face follow up at 28 days, with a further 19% receiving telephone follow up.